Ethyl Acetate → HCID 10797557, compound

HRID 278055Notes

Reaction equation

HRID 278055 reaction equation
C([O:4][CH2:5][C:6]1[O:7][C:8]2[C:14]([F:15])=[CH:13][CH:12]=[C:11]([F:16])[C:9]=2[CH:10]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>CO>[F:16][C:11]1[C:9]2[CH:10]=[C:6]([CH2:5][OH:4])[O:7][C:8]=2[C:14]([F:15])=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 10632977HCID 10632977, compound

Product 1

HCID 10797557HCID 10797557, compoundYield 78.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

252 mg of 2-acetoxymethyl-4,7-difluorobenzofuran was dissolved in 5 ml of methanol and 455 mg of potassium carbonate was added to the solution at room temperature. The resulting mixture was stirred at the same temperature for 2 hours, followed by the addition of ethyl acetate thereto. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, and evaporated. The resulting residue was subjected to silica gel chromatography (developer: 5% ethyl acetate/n-hexane) to give 161 mg of the title compound as a colorless oil.

Workup

  1. washThe organic layer was washed with brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-dd73ed22b67a46438c94567b72aaeeff
Source dataset
uspto-grants-2002_03
Patent number
US06358995B1

Reaction notes

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