Hydrochloric Acid → HCID 22627457, compound

HRID 278120Notes

Reaction equation

HRID 278120 reaction equation
C(OC([NH:8][C:9]1[CH:10]=[CH:11][C:12]2[C:16]([CH:17]=1)=[N:15][C:14](CC1C=CC=CC=1[Cl:28])([CH2:18][CH2:19][CH3:20])[C:13]=2[C:29](=[O:33])[CH:30]([CH3:32])[CH3:31])=O)(C)(C)C.[ClH:34]>C(OCC)(=O)C>[ClH:28].[NH2:8][C:9]1[CH:17]=[C:16]2[C:12]([C:13]([C:29](=[O:33])[CH:30]([CH3:32])[CH3:31])=[C:14]([CH2:18][CH2:19][CH3:20])[N:15]2[CH2:13][C:12]2[CH:16]=[CH:17][CH:9]=[CH:10][C:11]=2[Cl:34])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22627170HCID 22627170, compound

Product 1

HCID 22627457HCID 22627457, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 6-tert-butoxycarbonylamino-2-(2-chlorobenzyl)-3-isobutyryl-2-propylindole (110 mg) in ethyl acetate (1 ml) was added 4N hydrogen chloride in ethyl acetate at 20° C., and the mixture was stirred at the same temperature for 4 hours. The precipitates were collected by filtration and washed with ethyl acetate to give 6-amino-1-(2-chlorobenzyl)-3-isobutyryl-2-propylindole hydrochloride (50 mg) as powder.

Workup

  1. filtrationThe precipitates were collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-0c1640b9397b432eabb2e0bd8553263f
Source dataset
uspto-grants-2002_03
Patent number
US06358992B1

Reaction notes

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