反应详情

A solution of {2-[3-(4-cyano-3-fluoro-benzyl)-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester (1.0 g, 0.0029 mol) in EtOAc (30 mL) was cooled to −20° C. and saturated with HCl gas. The cooling bath was removed and the reaction was stirred for 2 h. The solvent was removed in vacuo to obtain the title compound which was used without further purification.

1. customThe cooling bath was removed
2. customThe solvent was removed in vacuo