Hydrochloric Acid → HCID 18187827, compound

HRID 278211Notes

Reaction equation

HRID 278211 reaction equation
[CH2:1]([CH:4]1[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)[CH:2]=[CH2:3].Br[C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1.[ClH:26]>>[ClH:26].[C:22]([C:21]1[CH:24]=[CH:25][C:18]([CH2:3][CH2:2][CH2:1][CH:4]2[CH2:5][CH2:6][NH:7][CH2:8][CH2:9]2)=[CH:19][CH:20]=1)#[N:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 12162Benzonitrile, 4-bromo-HCID 11117722tert-Butyl 4-(prop-2-en-1-yl)piperidine-1-carboxylate

Product 1

HCID 18187827HCID 18187827, compound

Procedure

Starting with 4-(prop-2-en-1-yl)-1-t-butoxycarbonylpiperidine from Procedure 5, Step B (475 mg, 2.1 mmol) and using essentially the same methods as in Procedure 5, Step D, but substituting 4-bromobenzonitrile (382 mg, 2.1 mmol), the title compound (337 mg) was obtained as the hydrochloride.

Sources & evidence

ORD record
ord-36e038c00f2b4d729aea1d22874b33ac
Source dataset
uspto-grants-2002_03
Patent number
US06358979B1

Reaction notes

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