Hydrochloric Acid → HCID 131723149, compound

HRID 278265Notes

Reaction equation

HRID 278265 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][CH3:22])=[N:17]1)[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21912727HCID 21912727, compound

Product 1

HCID 131723149HCID 131723149, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-(t-butoxycarbonyl)-4-(1,3-diethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (348 mg) (from Step E) in 2.5 N HCl in methanol was stirred at rt for 16 h. The solution was concentrated and the resulting solid was suspended in ethyl acetate, filtered and dried to afford 293 mg (92%) of the title compound.

Workup

  1. concentrationThe solution was concentrated
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-1398036eb6344e37bc434aa85c432c23
Source dataset
uspto-grants-2002_03
Patent number
US06358979B1

Reaction notes

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