反应详情

1.2 g of 3-methylisooxazol-5-yl-2,4,8-nonanetrione obtained in Example 6 was dissolved in 15 ml of ethanol, and 0.53 g of triethylamine was added to it to stir at reflux for 8 hours. After cooling, the reaction solution was poured into ice water, acidified with hydrochloric acid and extracted with ethyl acetate. The ethyl-acetate layer was washed with water, dehydrated over anhydrous magnesium sulfate, and concentrated. The obtained residue was purified on silica gel column chromatography to give 0.36 g of the title compound as white crystals. Melting point: 104-105° C.

1. temperatureat reflux for 8 hours
2. temperatureAfter cooling
3. extractionextracted with ethyl acetate
4. washThe ethyl-acetate layer was washed with water
5. concentrationconcentrated
6. customThe obtained residue was purified on silica gel column chromatography