Triethylamine → n-Neopentanoyl-2-octyldodecylamine

HRID 278532Notes

Reaction equation

HRID 278532 reaction equation
[C:1](Cl)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[CH2:8]([CH:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:17][NH2:18])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].C(N(CC)CC)C>CCCCCCC>[C:1]([NH:18][CH2:17][CH:16]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62493Pivaloyl chlorideHCID 187619992-n-Octyl-1-dodecylamine

Product 1

HCID 18673285n-Neopentanoyl-2-octyldodecylamine

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

62 ml of pivaloyl chloride were dissolved in 180 ml of heptane and then added to 150 g of 2-octyldodecylamine at a temperature of 60° C. After addition of 70 ml of triethylamine, the reaction medium was stirred for 2 hours and then purified on silica. 118 g of the desired amide were thus obtained.

Workup

  1. custompurified on silica

Sources & evidence

ORD record
ord-1ca69a6d98714be3b987c3f804e061c4
Source dataset
uspto-grants-2002_03
Patent number
US06359175B1

Reaction notes

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