反应详情

To a solution of 1-(tert-butoxycarbonyl)-4-(4-diisopropylaminomethylbenzoyl)piperazine (4.6 g) in ethyl acetate (10 ml) was added trifluoroacetic acid (20 ml), and the solution was stirred at room temperature for 1 hour and concentrated. The residue was dissolved in water. The solution was made alkaline with sodium hydroxide solution, extracted with dichloromethane. The extract was dried and concentrated to give amorphous powders which were filtered, washed with hexane and dried to afford the title compound (3.12 g).

1. concentrationconcentrated
2. dissolutionThe residue was dissolved in water
3. extractionextracted with dichloromethane
4. customThe extract was dried
5. concentrationconcentrated
6. customto give amorphous powders which
7. filtrationwere filtered
8. washwashed with hexane
9. customdried