Hydrochloric Acid → 4-(Pyridin-4-yl)benzoic acid

HRID 278566Notes

Reaction equation

HRID 278566 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[OH-].[Na+].C(O)C.Cl>O>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 15294733HCID 15294733, compound

Product 1

HCID 15208114-(Pyridin-4-yl)benzoic acidYield 86.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of ethyl 4-(4-pyridyl)benzoate (1.0 g), 1 N NaOH (8.8 ml) and ethanol (8.8 ml) was stirred at room temperature for 1 hour and diluted with water, to which was added 1 N hydrochloric acid (8.8 ml) to give the title compound as crystals (0.76 g, 86.4%).

Sources & evidence

ORD record
ord-47b8215a62514fafbc02729a6eb96e79
Source dataset
uspto-grants-2002_03
Patent number
US06359134B1

Reaction notes

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