反应详情

To a mixture of 1-(4-diisopropylaminomethylbenzoyl)piperazine (200 mg) in 10% sodium hydrogen carbonate solution (10 ml) and ethyl acetate (15 ml), was added 6-bromonaphthalene-2-sulfonylchloride (179 mg), and the solution was stirred at room temperature for 30 minutes. The organic layer was separated, washed with water and extracted with 1 N hydrochloric acid. The extract was made alkaline with sodium hydroxide solution and extracted with dichloromethane. The extract was dried and concentrated. The residue was crystallized with ether to give the title compound (201 mg), as colorless crystals.

1. customThe organic layer was separated
2. washwashed with water
3. extractionextracted with 1 N hydrochloric acid
4. extractionextracted with dichloromethane
5. customThe extract was dried
6. concentrationconcentrated
7. customThe residue was crystallized with ether