反应详情

温度

105 °C

A mixture of 4-cyano-4-phenylpiperidine hydrochloride (111 g, 0.5 mol), 3-bromopropylphthalimide (135.39 g, 0.505 mol), potassium carbonate (276.42 g, 2 mol), and potassium iodide (5.4 g) in DMF (1 L) was stirred and heated at 100-110° C. for 8 hours. About 80% of the solvent was evaporated at reduced pressure, the residue was diluted with dichloromethane (1 L) and washed with brine (3×300 mL) and dried (Na2SO4). Solvent was evaporated from the dichloromethane solution and the residue was treated with isopropanol (400 mL) and cooled. The pale yellow crystalline product formed was filtered, washed with ice-cold isopropanol and dried (168.6 g, 90%); M.p. 96-98° C.

1. customAbout 80% of the solvent was evaporated at reduced pressure
2. additionthe residue was diluted with dichloromethane (1 L)
3. washwashed with brine (3×300 mL)
4. dry with materialdried (Na2SO4)
5. customSolvent was evaporated from the dichloromethane solution
6. additionthe residue was treated with isopropanol (400 mL)
7. temperaturecooled
8. customThe pale yellow crystalline product formed
9. filtrationwas filtered
10. washwashed with ice-cold isopropanol
11. customdried (168.6 g, 90%)