Hydrochloric Acid → HCID 18001373, compound

HRID 278939Notes

Reaction equation

HRID 278939 reaction equation
Cl.[O:2]1[CH2:7][CH2:6]OCC1.[CH2:8]1[CH2:12]O[CH2:10][CH2:9]1.[CH:13]([OH:16])([CH3:15])[CH3:14]>>[OH:16][C:13]1[CH:15]=[C:9]([CH3:10])[CH:8]=[CH:12][C:14]=1[CH2:6][CH2:7][OH:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 22597222Tetrahydrofuran 2-propanol

Product 1

HCID 18001373HCID 18001373, compound

Procedure

Part C. A solution of the MOM compound from Part B (1.84 g, 9.38 mmol) was dissolved in 1:1 THF-isopropanol (20 mL), and treated with HCl in dioxane (2.5 mL, 4 N, 10.0 mmol). The reaction was stirred at ambient temperature overnight. Aqueous workup gave sufficiently pure product, 2-(2-hydroxy-4-methylphenyl)ethanol.

Sources & evidence

ORD record
ord-36d7294ee27e4f91a31ea85d3fb24721
Source dataset
uspto-grants-2002_03
Patent number
US06362180B1

Reaction notes

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