反应详情

A mixture of 0.98 g (5 mmoles) of 3-morpholino-6-pyridazinyl-hydrazine, 0.65 g (5 mmoles) of ethyl acetoacetate and 15 ml of ethanol is stirred at reflux temperature for 3 hours. After cooling the mixture is stirred with 1 ml of concentrated aqueous ammonium hydroxide solution at room temperature for 4 hours and then left to stand overnight. The separated crystals are filtered, washed with water and recrystallized from ethanol. Yield: 0.5 g (39%); m.p.: 189°-192° C.

1. temperatureat reflux temperature for 3 hours
2. temperatureAfter cooling the mixture
3. waitleft
4. filtrationThe separated crystals are filtered
5. washwashed with water
6. customrecrystallized from ethanol