Hydrochloric Acid → HCID 22623980, compound

HRID 279003Notes

Reaction equation

HRID 279003 reaction equation
C(=O)([O-])[O-].[K+].[K+].[OH:7][N:8]1[C:17](=[O:18])[C:16]2[CH:19]=[C:20]([O:22][CH2:23][CH2:24][O:25]C(=O)C)[CH:21]=[C:14]3[C:15]=2[C:10](=[CH:11][CH:12]=[CH:13]3)[C:9]1=[O:29].Cl>CO>[OH:7][N:8]1[C:17](=[O:18])[C:16]2[CH:19]=[C:20]([O:22][CH2:23][CH2:24][OH:25])[CH:21]=[C:14]3[C:15]=2[C:10](=[CH:11][CH:12]=[CH:13]3)[C:9]1=[O:29]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 22624025HCID 22624025, compound

Product 1

HCID 22623980HCID 22623980, compoundYield 73.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of potassium carbonate (0.4 g, 2.9 mmol) and 2-hydroxy-5-(2-acetoxy-ethoxy)-benzo[de]isoquinoline-1,3-dione (0.3 g, 1.0 mmol, from Example 23) in methanol (20 mL) was stirred for 2 hours. The mixture was acidified with 1N HCl to pH 4. The precipitate formed was filtered, washed with water, and dried to give 0.2 g of the title compound, mp 242-244° C.;

Workup

  1. customThe precipitate formed
  2. filtrationwas filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-b3b8bfe0608845329dcf0d9bdd2b30ad
Source dataset
uspto-grants-2002_03
Patent number
US06362181B1

Reaction notes

Loading…