反应详情

温度

65 °C

To 30 mL of anhydrous tetrahydrofuran was added 940 mg (39 mmol) of magnesium powder. The one-fifth of a solution obtained by dissolving 10 g (38 mmol) of 2-benzyloxybromobenzene in 30 mL of anhydrous tetrahydrofuran was added. To the resulting mixture were added 0.1 mL of 1,2-dibromoethane and a small amount of iodine, followed by heating to 60 to 70° C. When the reaction started, the remaining portion of the anhydrous tetrahydrofuran solution of 2-benzyloxybromobenzene was added dropwise and the mixture was heated to reflux for further 30 minutes. In the resulting anhydrous tetrahydrofuran solution of Grignard reagent, 7 g (37 mmol) of 1-benzyl-4-piperidone dissolved in 30 mL of anhydrous tetrahydrofuran was added dropwise at room temperature. After heating to reflux for 30 minutes, 10 mL of a saturated aqueous solution of ammonium chloride was added dropwise and the solvent was concentrated under reduced pressure. Water was added to the residue and the mixture was extracted with ether, followed by washing with water and drying. The residue obtained by concentrating the solvent under reduced pressure was purified by chromatography on a silica gel column, whereby 12 g (yield: 87.0%) of 1-benzyl-4-(2-benzyloxyphenyl)-4-piperidinol was obtained.

1. customThe one-fifth of a solution obtained
2. additionwas added
3. temperaturethe mixture was heated
4. temperatureto reflux for further 30 minutes
5. additionwas added dropwise at room temperature
6. temperatureAfter heating
7. temperatureto reflux for 30 minutes
8. concentrationthe solvent was concentrated under reduced pressure
9. additionWater was added to the residue
10. extractionthe mixture was extracted with ether
11. washby washing with water
12. customdrying
13. customThe residue obtained
14. concentrationby concentrating the solvent under reduced pressure
15. customwas purified by chromatography on a silica gel column