Tetrafluoroisophthalic acid → HCID 10130865, compound

HRID 279487Notes

Reaction equation

HRID 279487 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([F:11])[C:5]([C:12]([OH:14])=[O:13])=[C:4]([F:15])[C:3]=1[F:16].[CH3:17][Mg]Cl>C1COCC1>[F:11][C:6]1[C:5]([C:12]([OH:14])=[O:13])=[C:4]([F:15])[C:3]([F:16])=[C:2]([CH3:17])[C:7]=1[C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 297552Tetrafluoroisophthalic acidHCID 178418332HCID 178418332, compound

Product 1

HCID 10130865HCID 10130865, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

20 g of tetrafluoroisophthalic acid are initially charged in 250 ml of THF and, at from 20 to 40° C., admixed with 88 ml of a 3 molar methylmagnesium chloride solution. Customary aqueous work-up (see Example 3) gives 20.1 g of 2,4,5-trifluoro-6-methylisophthalic acid. The purity of the product is 85% by HPLC.

Sources & evidence

ORD record
ord-77d6ae5fa95046f9b9314c9da16b70f2
Source dataset
uspto-grants-2002_03
Patent number
US06362365B1

Reaction notes

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