反应详情

5 g of adenosine-5'-carboxylic acid are dissolved in 200 ml of n-hexanol and 2 ml of concentrated sulfuric acid and heated to 100° C. for 3 hours. After cooling, the reaction mixture is neutralized with triethylamine and left to stand overnight, the desired n-hexyl ester and triethylamine sulfate thereby crystallizing out. After filtering off with suction, the triethylamine sulfate is washed out with water and the remaining ester is recrystallized from methanol. There are obtained 3.1 g (48% of theory) of adenosine-5'-carboxylic acid n-hexyl ester, which has a melting point of 145°-147° C.

1. temperatureAfter cooling
2. waitleft
3. customthe desired n-hexyl ester and triethylamine sulfate thereby crystallizing out
4. filtrationAfter filtering off with suction
5. washthe triethylamine sulfate is washed out with water
6. customthe remaining ester is recrystallized from methanol