Hydrochloric Acid → HCID 14631382, compound

Temperature

-5 °C

Hydrogen chloride gas was bubbled into a mixture containing 24 g (200 mmol) of (2-methoxyethoxy)ethanol, 6.0 g (200 mmol) of paraformaldehyde and 22 g (200 mmol) of powdered calcium chloride with stirring and cooling to -5° C. The HCl was continued for 4 hours as the temperature was allowed to rise gradually to 8° C. Celite was added and the reaction filtered. The filtrate was evaporated leaving 29.8 g of a cloudy oil. The oil was dissolved in methylene chloride and dried over molecular sieves. Evaporation furnished 19.3 g of [2-(2-methoxyethoxy)ethoxy]methyl chloride as an oil which was characterized by nuclear magnetic resonance.

1. customHydrogen chloride gas was bubbled into a mixture
2. customto rise gradually to 8° C
3. additionCelite was added
4. filtrationthe reaction filtered
5. customThe filtrate was evaporated
6. customleaving 29.8 g of a cloudy oil
7. customdried over molecular sieves
8. customEvaporation

ORD record

ord-f6bf9af3c37e4176ac961fcb590948dc

Source dataset

uspto-grants-1986_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04587247