反应详情

Ten g. of 2-dimethylaminomethyl-4-(2-aminoethyl)thiomethylthiazole was dissolved in 100 ml. of isopropanol, and 2.8 ml. of methanesulfonic acid was added, followed by 6.5 g. of methylcarbonimidodithioic acid, dimethyl ester. The mixture was stirred under reflux for 16 hours, and was evaporated under vacuum to obtain a residue, which was taken up in 100 ml. of water. The solution was extracted with two 25 ml. portions of dichloromethane, and the aqueous layer was cooled. Fifty ml. of dichloromethane and 15 ml. of 50% aqueous sodium hydroxide were added. The layers were separated, and the solution was extracted again with 50 ml. of dichloromethane. The organic layers were combined, dried over potassium carbonate and evaporated under vacuum to obtain 10.3 g. of product, substantially identical to that of Example 1, which was 96.7% pure by HPLC analysis.

1. temperatureunder reflux for 16 hours
2. customwas evaporated under vacuum
3. customto obtain a residue, which
4. extractionThe solution was extracted with two 25 ml
5. temperatureportions of dichloromethane, and the aqueous layer was cooled
6. additionof 50% aqueous sodium hydroxide were added
7. customThe layers were separated
8. extractionthe solution was extracted again with 50 ml
9. dry with materialdried over potassium carbonate
10. customevaporated under vacuum
11. customto obtain 10.3 g