Methanol → HCID 135833480, compound

HRID 279948Notes

Reaction equation

[NH2:1][C:2]1[N:11]=[C:10](N)[C:9]2[C:4](=[N+:5]([O-])[CH:6]=[C:7]([CH2:13][O:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:8]=2)[N:3]=1.NC(N)=N.C[OH:25]>>[NH2:1][C:2]1[NH:11][C:10](=[O:25])[C:9]2[NH:8][CH:7]([CH2:13][O:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:6][NH:5][C:4]=2[N:3]=1

Participants

Reactant 3

HCID 887Methanol

HCID 3520Guanidine

HCID 178450417HCID 178450417, compound

Product 1

HCID 135833480HCID 135833480, compound

Procedure

2,4-Diamino-6-n-butoxymethylpteridine-8-oxide. The product of Example 4A was reacted with guanidine in methanol according to the procedure described in Example 2 to give the title compound; mp >250°. UV: (0.1N HCl) λmax 252.5 (30,900), 282 (10,700), 343.5 (sh) (6,200), 356.5 (8,500), 369.5 (7,800) nm. NMR: δ (d6 -DMSO) 0.88 (t, 3H); 1.0-1.8 (m, 4H); 3.51 (t, 2H); 4.49 (s, 2H); 7.01 (br s, 2H); 7.75 (br s, 2H); 8.37 (s, 1H). IR: (KBr) 3700-2800, 1632, 1546, 1461, 1356, 1331, 1163, 1053, 978 cm-1. Anal. calcd. for C11H16N6O2 : C, 49.99; H, 6.10; N, 31.80. Found: C, 49.79; H, 6.11; N, 31.67.

Sources & evidence

ORD record: ord-c81aa2bc76e7448b8c31877cf7c6e790
Source dataset: uspto-grants-1986_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04587340

Reaction notes

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