Ammonia → HCID 20195198, compound

HRID 280444Notes

Reaction equation

HRID 280444 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([S:14](Cl)(=[O:16])=[O:15])[C:5]2[O:10][S:9](=[O:12])(=[O:11])[CH:8]=[CH:7][C:6]=2[CH:13]=1.[NH3:18].Cl>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]([S:14](=[O:16])(=[O:15])[NH2:18])[C:5]2[O:10][S:9](=[O:12])(=[O:11])[CH:8]=[CH:7][C:6]=2[CH:13]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 20195206HCID 20195206, compound

Product 1

HCID 20195198HCID 20195198, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The crystalline product obtained in (c) is dissolved in as small an amount of tetrahydrofuran as possible and the solution is added dropwise to 20 ml of 25% aqueous ammonia solution. After the reaction mixture has been stirred for 30 minutes it is poured into a mixture of ice and 10% hydrochloric acid. Extraction with ether yields 0.3 g of 6-bromo-8-sulfamoyl-2,2-dioxo-1,2-benzoxathiine of m.p. 224°-228° C. (decomposition with black colouration).

Workup

  1. extractionExtraction with ether

Sources & evidence

ORD record
ord-037a6fadecc54d7a9bb5d1cddbc7b7eb
Source dataset
uspto-grants-1986_05
Patent number
US04589911

Reaction notes

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