反应详情

Into a 250 ml reaction flask equipped with stirrer, thermometer, reflux condenser and heating mantle are placed 86 grams of cyclopentanol; 25 grams of 2-mercaptopropionic acid; and 1 gram of paratoluene sulfonic acid. The reaction mass is heated to reflux and refluxed for a period of 8 hours. At the end of the 8 hour reflux period, the reaction mass is cooled and admixed with 200 ml diethylether followed by washing with two 100 ml volumes of 10% aqueous sodium carbonate and one 100 ml volume of water. The reaction mass is dried over anhydrous sodium sulfate and the solvent is recovered on a Buchi apparatus. The reaction mass is then micro distilled yielding the product having the structure: ##STR135##

1. customInto a 250 ml reaction flask
2. customequipped with stirrer
3. temperaturethermometer, reflux condenser
4. temperatureheating mantle
5. temperatureThe reaction mass is heated
6. temperatureto reflux
7. temperaturerefluxed for a period of 8 hours
8. temperatureAt the end of the 8 hour reflux period
9. temperaturethe reaction mass is cooled
10. washby washing with two 100 ml volumes of 10% aqueous sodium carbonate and one 100 ml volume of water
11. dry with materialThe reaction mass is dried over anhydrous sodium sulfate
12. customthe solvent is recovered on a Buchi apparatus
13. distillationThe reaction mass is then micro distilled
14. customyielding the product