Hydrochloric Acid → HCID 86740809, compound

HRID 280524Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[C@@H:15]([OH:16])[C:14](=[O:17])[N:13]([CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[C:12]3[CH:23]=[CH:24][CH:25]=[C:26]([F:27])[C:11]=3[S:10]2)=[CH:5][CH:4]=1.[ClH:28].[C:29](OC(=O)C)(=[O:31])[CH3:30]>>[ClH:28].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[C@@H:15]([O:16][C:29](=[O:31])[CH3:30])[C:14](=[O:17])[N:13]([CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[C:12]3[CH:23]=[CH:24][CH:25]=[C:26]([F:27])[C:11]=3[S:10]2)=[CH:5][CH:4]=1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 7918Acetic Anhydride

HCID 70482235HCID 70482235, compound

Product 1

HCID 86740809HCID 86740809, compound

Procedure

A mixture of 1 g of (±)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-9-fluoro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one and 10 ml of acetic anhydride is treated in the same manner as described in Example 54. The crude product is converted to its hydrochloride and recrystallized from a mixture of isopropanol and ether. 0.729 g of (±)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-9-fluoro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride is obtained.

Workup

additionis treated in the same manner
customrecrystallized from a mixture of isopropanol and ether

Sources & evidence

ORD record: ord-b7246b04fc1348ebbb4f0bd7c9641624
Source dataset: uspto-grants-1986_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04590188

Reaction notes

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