Sodium Bicarbonate → 7-Bromo-2-dimethylaminomethyl-1-tetralone

HRID 280628Notes

Reaction equation

HRID 280628 reaction equation
Cl.[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]([CH2:14][N:15]([CH3:17])[CH3:16])[C:10]2=[O:13])=[CH:5][CH:4]=1.C(=O)(O)[O-].[Na+]>O>[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]([CH2:14][N:15]([CH3:17])[CH3:16])[C:10]2=[O:13])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 233209337-Bromo-2-dimethylaminomethyl-1-tetralone hydrochloride

Product 1

HCID 136630577-Bromo-2-dimethylaminomethyl-1-tetralone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The hydrochloride was converted to the free base by dissolving in a small volume of water and adding a slight excess of a saturated aqueous solution of sodium bicarbonate. Ether extraction gave the free base as an oil.

Workup

  1. extractionEther extraction

Sources & evidence

ORD record
ord-db0c8c3ecc994e628a5282a8005ae732
Source dataset
uspto-grants-1986_05
Patent number
US04590200

Reaction notes

Loading…