Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)- → Benzene, 1-chloro-2,3-difluoro-5-(trifluoromethyl)-

HRID 280730Notes

Reaction equation

HRID 280730 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:6](Cl)[C:7]=1[F:8].[F-:14].[K+]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:6]([F:14])[C:7]=1[F:8]

Participants

3

Reactant 2

HCID 157026Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)-HCID 522689Potassium Fluoride

Product 1

HCID 2736496Benzene, 1-chloro-2,3-difluoro-5-(trifluoromethyl)-

Procedure

reacting the 3,5-dichloro-4-fluorobenzotrifluoride product of step (B) with potassium fluoride in the liquid phase at a temperature of about 170° to about 270° Celsius to form 3-chloro-4,5-difluorobenzotrifluoride.

Workup

  1. customat a temperature of about 170° to about 270° Celsius

Sources & evidence

ORD record
ord-f6eb4f2577714fa0a6ea6d91fc67f050
Source dataset
uspto-grants-1986_05
Patent number
US04590315

Reaction notes

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