反应详情

To a mixture of 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid (2.77 mmol), potassium carbonate (3.25 mmol) and hexamethylphosphoric triamide (HMPT) (3 ml), with stirring and under nitrogen, at RT, is added 2-fluoro-5-phenoxybenzyl bromide (2.77 mmol) in THF. The reaction is stirred at RT for about 48 hours and then worked up by partition between water/ether. The organic phase is washed with water and brine, dried over potassium carbonate, filtered and the solvent is removed from the filtrate. The residue is plated on prep. TLC plates developing with 10% ether/hexane to yield 2-fluoro-5-phenoxybenzyl 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylate.

1. stirringThe reaction is stirred at RT for about 48 hours
2. customby partition between water/ether
3. washThe organic phase is washed with water and brine
4. dry with materialdried over potassium carbonate
5. filtrationfiltered
6. customthe solvent is removed from the filtrate