Triethylamine → N-(4-chlorophenyl)-N-(1-propyl-4-piperidinyl)benzeneacetamide hydrochloride

HRID 28151ノート

反応式

HRID 28151 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.C(N(CC)CC)C.I[CH2:32][CH2:33][CH3:34]>C1C=CC=CC=1>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:32][CH2:33][CH3:34])[CH2:20][CH2:19]2)[C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 336431-Iodopropane2 回HCID 162188N-(4-Chlorophenyl)-N-4-piperidinylbenzeneacetamide

生成物 1

HCID 23339041N-(4-chlorophenyl)-N-(1-propyl-4-piperidinyl)benzeneacetamide hydrochloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a stirred solution of 4 parts of N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide and 3 parts of N,N-diethylethanamine in 200 parts of benzene are added portionwise 4 parts of 1-iodopropane and the whole is stirred and refluxed for 47 hours. Then the second portion of 4 parts of 1-iodopropane is added and stirring and refluxing is continued for another 20 h.20. The reaction mixture is cooled and filtered. The filtrate is washed with water, dried and evaporated in vacuo. From the oily free base, the hydrochloride salt is prepared in the conventional manner in 1,1'-oxybisethane. The precipitated solid salt is filtered off and dried, yielding 3.5 parts of N-(4-chlorophenyl)-N-(1-propyl-4-piperidinyl)benzeneacetamide hydrochloride; mp. 233.5° C.

後処理

  1. temperaturerefluxed for 47 hours
  2. stirringstirring
  3. temperaturerefluxing
  4. temperatureThe reaction mixture is cooled
  5. filtrationfiltered
  6. washThe filtrate is washed with water
  7. customdried
  8. customevaporated in vacuo
  9. filtrationThe precipitated solid salt is filtered off
  10. customdried

出典と根拠

ORDレコード
ord-e2192b2ec0f648c4994e1497b6c9c192
出典データセット
uspto-grants-1980_09
特許番号
US04225606

反応ノート

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