Triethylamine → N-(3-(1-(2-(7-Methoxyquinolin-4-yloxy)ethyl)-6-oxo-1,6-dihydropyridin-3-yl)prop-2-ynyl)-2-(pyrrolidin-1-yl)acetamide

HRID 281800Notes

Reaction equation

HRID 281800 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](=[O:23])[n:6]([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][n:14][c:15]3[cH:16][c:17]([O:21][CH3:22])[cH:18][cH:19][c:20]23)[cH:7]1.[CH2:31]([C:32]#[CH:33])[NH:34][C:35]([CH2:36][N:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1)=[O:42].[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[Cu:43][I:44]>>[c:2]1([C:33]#[C:32][CH2:31][NH:34][C:35]([CH2:36][N:37]2[CH2:38][CH2:39][CH2:40][CH2:41]2)=[O:42])[cH:3][cH:4][c:5](=[O:23])[n:6]([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][n:14][c:15]3[cH:16][c:17]([O:21][CH3:22])[cH:18][cH:19][c:20]23)[cH:7]1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 248844955-Bromo-1-(2-(7-methoxyquinolin-4-yloxy)ethyl)pyridin-2(1H)-oneHCID 77174863N-(prop-2-ynyl)-2-(pyrrolidin-1-yl)acetamide

Product 1

HCID 25018641N-(3-(1-(2-(7-Methoxyquinolin-4-yloxy)ethyl)-6-oxo-1,6-dihydropyridin-3-yl)prop-2-ynyl)-2-(pyrrolidin-1-yl)acetamide

Sources & evidence

ORD record
ord-ed28edd8a21a499e8ab69fbdab79d9f9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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