Hydrochloric Acid → 5-Bromo-2-{4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]anilino}-4-(4-methoxyphenoxy)pyrimidine

HRID 281888Notes

Reaction equation

HRID 281888 reaction equation
[Br:1][c:2]1[c:3]([O:9][c:10]2[cH:11][cH:12][c:13]([O:16][CH3:17])[cH:14][cH:15]2)[n:4][c:5]([Cl:8])[n:6][cH:7]1.[CH3:34][N:35]1[CH2:36][CH2:37][CH2:38][C:39]1=[O:40].[ClH:18].[OH:19][CH:20]([CH2:21][O:22][c:23]1[cH:24][cH:25][c:26]([NH2:27])[cH:28][cH:29]1)[CH2:30][N:31]([CH3:32])[CH3:33]>>[Br:1][c:2]1[c:3]([O:9][c:10]2[cH:11][cH:12][c:13]([O:16][CH3:17])[cH:14][cH:15]2)[n:4][c:5]([NH:27][c:26]2[cH:25][cH:24][c:23]([O:22][CH2:21][CH:20]([OH:19])[CH2:30][N:31]([CH3:32])[CH3:33])[cH:29][cH:28]2)[n:6][cH:7]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 13387N-methyl-2-pyrrolidoneHCID 111951791-(4-Aminophenoxy)-3-(dimethylamino)propan-2-olHCID 729424805-Bromo-2-chloro-4-(4-methoxyphenoxy)pyrimidine

Product 1

HCID 101633555-Bromo-2-{4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]anilino}-4-(4-methoxyphenoxy)pyrimidine

Sources & evidence

ORD record
ord-af29983f3cd74ed0b24fd561d0dc23e1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…