Tetrahydrofuran → 1-Boc-3-(1-phenylethylamino)-4-piperidinemethanol

HRID 283241Notes

Reaction equation

HRID 283241 reaction equation
[Al+3:29].[H-:28].[H-:31].[H-:32].[H-:33].[Li+:30].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1.[c:1]1([CH:7]([CH3:8])[NH:9][CH:10]2[CH2:11][N:12]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:13][CH2:14][CH:15]2[C:16](=[O:17])[O:18][CH2:19][CH3:20])[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([CH:7]([CH3:8])[NH:9][CH:10]2[CH2:11][N:12]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:13][CH2:14][CH:15]2[CH2:16][OH:17])[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 23590625Ethyl 1-Boc-3-(1-phenylethylamino)piperidine-4-carboxylate

Product 1

HCID 668469491-Boc-3-(1-phenylethylamino)-4-piperidinemethanol

Sources & evidence

ORD record
ord-b9ba7480fc5942369087e0556bc2467e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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