Tetrahydrofuran → 6-bromo-2-(4-methanesulfonylbenzyl)-4-phenyl-3-(2,2,2-trifluoro-1-hydroxyethyl)-2H-isoquinolin-1-one

HRID 284027Notes

Reaction equation

HRID 284027 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5](-[c:26]3[cH:27][cH:28][cH:29][cH:30][cH:31]3)[c:6]([CH:24]=[O:25])[n:7]([CH2:13][c:14]3[cH:15][cH:16][c:17]([S:20](=[O:21])(=[O:22])[CH3:23])[cH:18][cH:19]3)[c:8](=[O:12])[c:9]2[cH:10][cH:11]1.[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[F:32][C:33]([F:34])([F:35])[Si:36]([CH3:37])([CH3:38])[CH3:39]>>[Br:1][c:2]1[cH:3][c:4]2[c:5](-[c:26]3[cH:27][cH:28][cH:29][cH:30][cH:31]3)[c:6]([CH:24]([OH:25])[C:33]([F:32])([F:34])[F:35])[n:7]([CH2:13][c:14]3[cH:15][cH:16][c:17]([S:20](=[O:21])(=[O:22])[CH3:23])[cH:18][cH:19]3)[c:8](=[O:12])[c:9]2[cH:10][cH:11]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 552549(Trifluoromethyl)trimethylsilaneHCID 230608166-Bromo-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbaldehyde

Product 1

HCID 230605936-bromo-2-(4-methanesulfonylbenzyl)-4-phenyl-3-(2,2,2-trifluoro-1-hydroxyethyl)-2H-isoquinolin-1-one

Sources & evidence

ORD record
ord-3e8aec5f46824232acb7d48a37e63641
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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