Sodium ion → 3-Fluoro-5-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-pyridine-4-carbaldehyde

HRID 284892Notes

Reaction equation

HRID 284892 reaction equation
[Br:20][c:21]1[cH:22][n:23][cH:24][c:25]([F:29])[c:26]1[CH:27]=[O:28].[CH3:1][C:2]1([CH3:3])[C:4]([CH3:5])([CH3:6])[O:7][B:8]([c:9]2[cH:10][c:11]3[c:15]([cH:16][cH:17]2)[C:14](=[O:18])[O:13][CH2:12]3)[O:19]1.[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[Na+:30].[Na+:31].[O-:32][C:33](=[O:34])[O-:35].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[c:9]1(-[c:21]2[cH:22][n:23][cH:24][c:25]([F:29])[c:26]2[CH:27]=[O:28])[cH:10][c:11]2[c:15]([cH:16][cH:17]1)[C:14](=[O:18])[O:13][CH2:12]2

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 534291923-Bromo-5-fluoropyridine-4-carboxaldehydeHCID 580746235-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-2-benzofuran-1-one

Product 1

HCID 866748373-Fluoro-5-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-pyridine-4-carbaldehyde

Sources & evidence

ORD record
ord-ddb097c265b24495ad961a49c396945f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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