Dichloromethane → N-[(3-Bromo-4-fluorophenyl)methyl]-N'-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}pentanediamide

HRID 285196Notes

Reaction equation

HRID 285196 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH2:9][NH:10][C:11]([CH2:12][CH2:13][CH2:14][C:15](=[O:16])[OH:17])=[O:18])[cH:5][cH:6][c:7]1[F:8].[CH2:77]1[O:78][CH2:79][CH2:80][CH2:81]1.[CH:65]([N:66]([CH:67]([CH3:68])[CH3:69])[CH2:70][CH3:71])([CH3:72])[CH3:73].[Cl:74][CH2:75][Cl:76].[NH2:43][CH2:44][c:45]1[c:46]([NH:58][CH:59]2[CH2:60][CH2:61][O:62][CH2:63][CH2:64]2)[c:47]2[c:48]([n:49][c:50]1[CH2:51][CH3:52])[n:53]([CH2:56][CH3:57])[n:54][cH:55]2.[P-:19]([F:20])([F:21])([F:22])([F:23])([F:24])[F:25].[n:26]1([O:27][C:28]([N:29]([CH3:30])[CH3:31])=[N+:32]([CH3:33])[CH3:34])[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]2[n:41][n:42]1>>[Br:1][c:2]1[cH:3][c:4]([CH2:9][NH:10][C:11]([CH2:12][CH2:13][CH2:14][C:15](=[O:17])[NH:43][CH2:44][c:45]2[c:46]([NH:58][CH:59]3[CH2:60][CH2:61][O:62][CH2:63][CH2:64]3)[c:47]3[c:48]([n:49][c:50]2[CH2:51][CH3:52])[n:53]([CH2:56][CH3:57])[n:54][cH:55]3)=[O:18])[cH:5][cH:6][c:7]1[F:8]

Participants

8

Reactant 7

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 578198715-{[(3-bromo-4-fluorophenyl)methyl]amino}-5-oxopentanoic AcidHCID 596832145-(Aminomethyl)-1,6-diethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

Product 1

HCID 57819876N-[(3-Bromo-4-fluorophenyl)methyl]-N'-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}pentanediamide

Sources & evidence

ORD record
ord-cf724087454b45a68e47aab2fa305793
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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