反应详情

To a solution of diethyl malonate (320 mg, 2 mmol) in tetrahydrofuran (15 ml) was added a solution of potassium tert-butoxide in tetrahydrofuran (1 M, 2.2 ml, 2.2 mmol). After stirring for 10 minutes, 4-bromonitrobenzene (404 mg, 2 mmol) was added. After stirring for 12 hours, the reaction was quenched by addition of saturated aqueous ammonium chloride solution (50 ml) and extracted with ethyl acetate (2×50 ml). The combined extracts were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to provide crude 2-(4-nitro-phenyl)-malonic acid diethyl ester.

1. stirringAfter stirring for 12 hours
2. customthe reaction was quenched by addition of saturated aqueous ammonium chloride solution (50 ml)
3. extractionextracted with ethyl acetate (2×50 ml)
4. dry with materialThe combined extracts were dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure