Trifluoroacetic acid → 7-(2-Fluoro-4-methylsulfonylphenyl)-4-(1-propan-2-ylsulfonylpiperidin-4-yl)oxy-5,6-dihydropyrrolo[2,3-d]pyrimidine

HRID 286414Notes

Reaction equation

HRID 286414 reaction equation
[CH3:44][CH:45]([CH3:46])[S:47](=[O:48])(=[O:49])[Cl:50].[CH:35]([N:36]([CH:37]([CH3:38])[CH3:39])[CH2:40][CH3:41])([CH3:42])[CH3:43].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[F:8][c:9]1[c:10]([N:19]2[CH2:20][CH2:21][c:22]3[c:23]2[n:24][cH:25][n:26][c:27]3[O:28][CH:29]2[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]2)[cH:11][cH:12][c:13]([S:15](=[O:16])(=[O:17])[CH3:18])[cH:14]1>>[F:8][c:9]1[c:10]([N:19]2[CH2:20][CH2:21][c:22]3[c:23]2[n:24][cH:25][n:26][c:27]3[O:28][CH:29]2[CH2:30][CH2:31][N:32]([S:47]([CH:45]([CH3:44])[CH3:46])(=[O:48])=[O:49])[CH2:33][CH2:34]2)[cH:11][cH:12][c:13]([S:15](=[O:16])(=[O:17])[CH3:18])[cH:14]1

Participants

5

Reactant 4

HCID 6422Trifluoroacetic acidHCID 81531DiisopropylethylamineHCID 824082-Propanesulfonyl chlorideHCID 690641277-(2-Fluoro-4-methylsulfonylphenyl)-4-piperidin-4-yloxy-5,6-dihydropyrrolo[2,3-d]pyrimidine

Product 1

HCID 248997487-(2-Fluoro-4-methylsulfonylphenyl)-4-(1-propan-2-ylsulfonylpiperidin-4-yl)oxy-5,6-dihydropyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-9eaf069f13c8431f8d921ca1ae1d88eb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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