Tetrahydrofuran → Methyl 2-[3-({2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidine-1-yl]phenoxy}methyl)phenoxy]propionate

HRID 286742Notes

Reaction equation

HRID 286742 reaction equation
[Cl:1][c:2]1[c:3]([OH:22])[cH:4][c:5](-[n:9]2[c:10](=[O:21])[n:11]([CH3:20])[c:12]([C:16]([F:17])([F:18])[F:19])[cH:13][c:14]2=[O:15])[c:6]([F:8])[cH:7]1.[O:57]=[C:58]([O:59][CH:60]([CH3:61])[CH3:62])[N:63]=[N:64][C:65]([O:66][CH:67]([CH3:68])[CH3:69])=[O:70].[O:71]1[CH2:72][CH2:73][CH2:74][CH2:75]1.[OH:23][CH2:24][c:25]1[cH:26][c:27]([O:28][CH:29]([C:30](=[O:31])[O:32][CH3:33])[CH3:34])[cH:35][cH:36][cH:37]1.[c:38]1([P:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[cH:52][cH:53][cH:54][cH:55][cH:56]1>>[Cl:1][c:2]1[c:3]([O:22][CH2:24][c:25]2[cH:26][c:27]([O:28][CH:29]([C:30](=[O:31])[O:32][CH3:33])[CH3:34])[cH:35][cH:36][cH:37]2)[cH:4][c:5](-[n:9]2[c:10](=[O:21])[n:11]([CH3:20])[c:12]([C:16]([F:17])([F:18])[F:19])[cH:13][c:14]2=[O:15])[c:6]([F:8])[cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 112677571-methyl-6-trifluoromethyl-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedioneHCID 18759680Methyl 2-(3-hydroxymethylphenoxy)propionate

Product 1

HCID 18759668Methyl 2-[3-({2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidine-1-yl]phenoxy}methyl)phenoxy]propionate

Sources & evidence

ORD record
ord-15adcdab4bc8433a89d47e29f3b1c799
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…