Water → 1-O-tert-butyl 2-O-methyl 4-(3-bromo-7-methoxyquinolin-2-yl)oxypyrrolidine-1,2-dicarboxylate

HRID 286871Notes

Reaction equation

HRID 286871 reaction equation
[Br:21][c:22]1[cH:23][cH:24][c:25]([S:26]([O:27][CH:32]2[CH2:33][CH:34]([C:44](=[O:45])[O:46][CH3:47])[N:35]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:36]2)(=[O:28])=[O:29])[cH:30][cH:31]1.[Br:7][c:8]1[c:9](=[O:20])[nH:10][c:11]2[cH:12][c:13]([O:18][CH3:19])[cH:14][cH:15][c:16]2[cH:17]1.[C:1](=[O:2])([O-:3])[O-:4].[CH3:48][CH2:49][O:50][C:51]([CH3:52])=[O:53].[CH3:54][N:55]1[CH2:56][CH2:57][CH2:58][C:59]1=[O:60].[Cs+:5].[Cs+:6].[OH2:61]>>[Br:7][c:8]1[c:9]([O:20][CH:32]2[CH2:33][CH:34]([C:44](=[O:45])[O:46][CH3:47])[N:35]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:36]2)[n:10][c:11]2[cH:12][c:13]([O:18][CH3:19])[cH:14][cH:15][c:16]2[cH:17]1

Participants

8

Reactant 7

HCID 962WaterHCID 8857Ethyl AcetateHCID 13387N-methyl-2-pyrrolidoneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 20752709HCID 20752709, compoundHCID 59287022HCID 59287022, compound

Product 1

HCID 722466421-O-tert-butyl 2-O-methyl 4-(3-bromo-7-methoxyquinolin-2-yl)oxypyrrolidine-1,2-dicarboxylate

Sources & evidence

ORD record
ord-478ad8946f474ac7afdfa9cfb7f6d11e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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