Diisopropylamine → 2-(4-Trifluoromethylphenyl)-5-pent-1-ynylpyrimidine
Reaction equation
[CH:134]([NH:135][CH:136]([CH3:137])[CH3:138])([CH3:139])[CH3:140].[CH:18]#[C:19][CH2:20][CH2:21][CH3:22].[Cu:132][I:133].[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[n:10][cH:11][c:12]([Br:15])[cH:13][n:14]2)[cH:7][cH:8]1)([F:16])[F:17].[F:23][c:24]1[c:25]([F:26])[c:27]([O:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[cH:37][cH:38][c:39]1-[c:40]1[n:41][cH:42][c:43]([C:44]#[C:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH3:52])[cH:53][n:54]1.[cH:55]1[cH:56][cH:57][c:58]([P:59]([Pd:60]([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([P:80]([c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)[c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[P:99]([c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)([c:106]2[cH:107][cH:108][cH:109][cH:110][cH:111]2)[c:112]2[cH:113][cH:114][cH:115][cH:116][cH:117]2)([c:118]2[cH:119][cH:120][cH:121][cH:122][cH:123]2)[c:124]2[cH:125][cH:126][cH:127][cH:128][cH:129]2)[cH:130][cH:131]1>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[n:10][cH:11][c:12]([C:18]#[C:19][CH2:20][CH2:21][CH3:22])[cH:13][n:14]2)[cH:7][cH:8]1)([F:16])[F:17]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-ee306f0f555846d4b3778c99375fe769
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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