Dimethyl methylphosphonate → HCID 44220860, compound

To a solution of dimethyl methylphosphonate (2.16 mL, 20 mmol) in anhydrous THF (30 mL), cooled at −78° C. was added n-BuLi (1.6 M in hexane, 13.75 mL, 22 mmol). The mixture was stirred for 30 minutes at this temperature under nitrogen. Methyl 5-chloropentanoate (1.50 g, 10 mmol) was added dropwise for 10 minutes. The mixture was stirred for 2 hours at −78° C., gradually was warm to room temperature. The mixture was quenched with addition of 1N HCl to pH 4-5. The organic layer was separated, washed with brine and dried over MgSO4. The residue was purified through flash chromatography on silica gel (MeOH:CH2Cl2=2:98) to give the product (1.60 g) with colorless oil in 17% yield. 1HNMR (CDCl3, ppm) δ 1.76 (m, 6H), 2.67 (t, J=6.6 Hz, 2H), 3.01 (d, J=21.7 Hz, 2H), 3.35 (t, J=6.2 Hz, 2H), 3.76 (s, 3H), 3.79 (s, 3H).

1. stirringThe mixture was stirred for 2 hours at −78° C.
2. customThe mixture was quenched with addition of 1N HCl to pH 4-5
3. customThe organic layer was separated
4. washwashed with brine
5. dry with materialdried over MgSO4
6. customThe residue was purified through flash chromatography on silica gel (MeOH:CH2Cl2=2:98)

ORD record

ord-36a76206b4bb487f8fa3f0480c2058d5

Source dataset

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07419999B2