Hydrochloric Acid → (1RS,4aRS,7aRS)-6-{{[3-(1-pyrrolidinyl)-2-propoxy]phenyl}acetyl}-4,4-diphenylperhydrothiopyrano[2,3-c]-pyrrole 1-oxide

HRID 287931Notes

Reaction equation

HRID 287931 reaction equation
[CH3:54][N:55]([CH3:56])[CH2:57][CH2:58][CH2:59][N:60]=[C:61]=[N:62][CH2:63][CH3:64].[Cl:65][CH2:66][Cl:67].[ClH:53].[N:34]1([CH2:39][CH:40]([CH3:41])[O:42][c:43]2[c:44]([CH2:49][C:50](=[O:51])[OH:52])[cH:45][cH:46][cH:47][cH:48]2)[CH2:35][CH2:36][CH2:37][CH2:38]1.[OH2:1].[OH:2][c:3]1[c:4]2[n:5][n:6][nH:7][c:8]2[cH:9][cH:10][cH:11]1.[c:12]1([C:18]2([c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)[CH2:19][CH2:20][S:21](=[O:27])[CH:22]3[CH2:23][NH:24][CH2:25][CH:26]23)[cH:13][cH:14][cH:15][cH:16][cH:17]1>>[c:12]1([C:18]2([c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)[CH2:19][CH2:20][S:21](=[O:27])[CH:22]3[CH2:23][N:24]([C:50]([CH2:49][c:44]4[c:43]([O:42][CH:40]([CH2:39][N:34]5[CH2:35][CH2:36][CH2:37][CH2:38]5)[CH3:41])[cH:48][cH:47][cH:46][cH:45]4)=[O:51])[CH2:25][CH:26]23)[cH:13][cH:14][cH:15][cH:16][cH:17]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 962WaterHCID 6344DichloromethaneHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 18995289(-)-4,4-Diphenylperhydrothiopyrano[2,3-c]pyrrole 1-oxideHCID 54259613{[3-(1-Pyrrolidinyl)-2-propoxy]phenyl}acetic acidHCID 178418300HCID 178418300, compound

Product 1

HCID 67745327(1RS,4aRS,7aRS)-6-{{[3-(1-pyrrolidinyl)-2-propoxy]phenyl}acetyl}-4,4-diphenylperhydrothiopyrano[2,3-c]-pyrrole 1-oxide

Sources & evidence

ORD record
ord-053d81db216245d0b21c74165414b145
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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