Hydrochloric Acid → 3-Morpholinone,5-(5-bromo-2-fluorophenyl)-5-(difluoromethyl)-

HRID 288388Notes

Reaction equation

HRID 288388 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:19])[c:6]([C:8]([CH:9]([F:10])[F:11])([CH2:12][OH:13])[NH:14][C:15]([CH2:16][Cl:17])=[O:18])[cH:7]1.[C:26]([OH:27])([CH3:28])([CH3:29])[CH3:30].[CH3:20][C:21]([CH3:22])([O-:23])[CH3:24].[CH3:31][CH2:32][O:33][C:34]([CH3:35])=[O:36].[ClH:37].[K+:25]>>[Br:1][c:2]1[cH:3][cH:4][c:5]([F:19])[c:6]([C:8]2([CH:9]([F:10])[F:11])[CH2:12][O:13][CH2:16][C:15](=[O:18])[NH:14]2)[cH:7]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 813Potassium CationHCID 6386tert-ButanolHCID 8857Ethyl AcetateHCID 45749132-Methylpropan-2-olateHCID 66665777N-[2-(5-bromo-2-fluorophenyl)-1,1-difluoro-3-hydroxypropan-2-yl]-2-chloroacetamide

Product 1

HCID 666657213-Morpholinone,5-(5-bromo-2-fluorophenyl)-5-(difluoromethyl)-

Sources & evidence

ORD record
ord-12a42e4f6e784091bd5ef862a4be0bd5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…