Water → Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)-4-hydroxycyclohexanecarboxylate

HRID 288412Notes

Reaction equation

HRID 288412 reaction equation
[Br:25][N:26]1[C:27](=[O:28])[CH2:29][CH2:30][C:31]1=[O:32].[CH3:34][CH2:35][O:36][C:37](=[O:38])[CH3:39].[O:20]=[CH:21][N:22]([CH3:23])[CH3:24].[OH2:33].[OH:1][C:2]1([c:15]2[s:16][cH:17][cH:18][n:19]2)[CH2:3][CH2:4][CH:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[OH:1][C:2]1([c:15]2[s:16][c:17]([Br:25])[cH:18][n:19]2)[CH2:3][CH2:4][CH:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 67184N-bromobutanimideHCID 67257275Tert-butyl 4-hydroxy-4-(1,3-thiazol-2-yl)cyclohexanecarboxylate

Product 1

HCID 70926225Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)-4-hydroxycyclohexanecarboxylate

Sources & evidence

ORD record
ord-c6876d5f189d43b2b35b13691d7b9048
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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