反应详情

In a 100-cm3 flask, 2.5 g of 4-oxo-4-(4-ethylphenyl)butyric acid are dissolved with magnetic stirring in 19 cm3 of trifluoroacetic acid. 3.2 g of triethylsilane are added dropwise. The reaction mixture is stirred for 86 hours at room temperature. It is poured into ice. It is extracted with 3 volumes of ether. The organic phases are washed 3 times with 10% potassium carbonate solution. The aqueous phases are combined and then acidified by adding concentrated hydrochloric acid until the pH is 3-4. The precipitate obtained is drained and then recrystallized.

1. additionIt is poured into ice
2. extractionIt is extracted with 3 volumes of ether
3. washThe organic phases are washed 3 times with 10% potassium carbonate solution
4. additionby adding concentrated hydrochloric acid until the pH is 3-4
5. customThe precipitate obtained
6. customrecrystallized