Tetrahydrofuran → 7-chloro-6-(2-fluoro-4-iodophenylamino)-3-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid
Reaction equation
[Br:20][c:21]1[c:22]([Cl:34])[c:23]2[c:24]([n:25][c:26]1[C:27](=[O:28])[OH:29])[n:30]([CH3:33])[cH:31][n:32]2.[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:11][Si:12]([N-:13][Si:14]([CH3:15])([CH3:16])[CH3:17])([CH3:18])[CH3:19].[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([I:9])[cH:8]1.[Li+:10]>>[F:1][c:2]1[c:3]([NH:4][c:21]2[c:22]([Cl:34])[c:23]3[c:24]([n:25][c:26]2[C:27](=[O:28])[OH:29])[n:30]([CH3:33])[cH:31][n:32]3)[cH:5][cH:6][c:7]([I:9])[cH:8]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-3e87945855654a1c8aac013b6d345879
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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