Hydrochloric Acid → Benzyl 4-chloro-3-(diethoxyphosphorylamino)piperidine-1-carboxylate

HRID 289873Notes

Reaction equation

HRID 289873 reaction equation
[CH2:1]([CH3:2])[O:3][P:4](=[O:5])([O:6][CH2:7][CH3:8])[N:9]1[CH:10]2[CH2:11][CH2:12][N:13]([C:16](=[O:17])[O:18][CH2:19][c:20]3[cH:21][cH:22][cH:23][cH:24][cH:25]3)[CH2:14][CH:15]12.[CH2:27]([N:28]([CH2:29][CH3:30])[CH2:31][CH3:32])[CH3:33].[Cl:34][CH2:35][Cl:36].[ClH:26]>>[CH2:1]([CH3:2])[O:3][P:4](=[O:5])([O:6][CH2:7][CH3:8])[NH:9][CH:15]1[CH:10]([Cl:26])[CH2:11][CH2:12][N:13]([C:16](=[O:17])[O:18][CH2:19][c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[CH2:14]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 8471TriethylamineHCID 59455678Benzyl 7-(diethoxyphosphoryl)-3,7-diazabicyclo[4.1.0]heptane-3-carboxylate

Product 1

HCID 67500461Benzyl 4-chloro-3-(diethoxyphosphorylamino)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-5585764a56664222b20013fd94422aaa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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