1,2-Dichloroethane → N-Ethyl-5-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-nicotinamide

HRID 290105Notes

Reaction equation

HRID 290105 reaction equation
[CH2:29]([Cl:30])[CH2:31][Cl:32].[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10](-[c:17]3[cH:18][n:19][cH:20][c:21]([C:22](=[O:23])[OH:24])[cH:25]3)[c:11]3[c:12]([n:13]2)[nH:14][cH:15][cH:16]3)[n:7]1.[CH3:26][CH2:27][NH2:28].[CH3:44][C:45]#[N:46].[ClH:33].[OH:34][n:35]1[c:36]2[c:37]([cH:38][cH:39][cH:40][cH:41]2)[n:42][n:43]1>>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10](-[c:17]3[cH:18][n:19][cH:20][c:21]([C:22](=[O:23])[NH:28][CH2:27][CH3:26])[cH:25]3)[c:11]3[c:12]([n:13]2)[nH:14][cH:15][cH:16]3)[n:7]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 6341EthylamineHCID 6342AcetonitrileHCID 757711-HydroxybenzotriazoleHCID 687615905-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-nicotinic acid

Product 1

HCID 44194351N-Ethyl-5-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-nicotinamide

Sources & evidence

ORD record
ord-f659f1e6229348f79746dd0fcf030843
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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