Tetrahydrofuran → 2-(((4-(2-(8-ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzimidazole

HRID 290276Notes

Reaction equation

HRID 290276 reaction equation
[CH2:1]([CH3:2])[C:3]1([CH2:13][CH2:14][O:15][c:16]2[c:17]([CH3:24])[c:18]([CH2:22][OH:23])[n:19][cH:20][cH:21]2)[O:4][CH2:5][C:6]2([O:7][CH2:8][CH2:9][O:10]2)[CH2:11][O:12]1.[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[CH3:32][S:33](=[O:34])(=[O:35])[Cl:36].[SH:37][c:38]1[nH:39][c:40]2[c:41]([n:42]1)[cH:43][cH:44][cH:45][cH:46]2>>[CH2:1]([CH3:2])[C:3]1([CH2:13][CH2:14][O:15][c:16]2[c:17]([CH3:24])[c:18]([CH2:22][S:37][c:38]3[n:39][c:40]4[c:41]([nH:42]3)[cH:43][cH:44][cH:45][cH:46]4)[n:19][cH:20][cH:21]2)[O:4][CH2:5][C:6]2([O:7][CH2:8][CH2:9][O:10]2)[CH2:11][O:12]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 59792375(4-(2-(8-Ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methanolHCID 178527775HCID 178527775, compound

Product 1

HCID 597925652-(((4-(2-(8-ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzimidazole

Sources & evidence

ORD record
ord-4cc00e3fdf6a4b45910237aabd23a040
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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