Hydrochloric Acid → 4-(5-(1-(3,3-Difluorocyclobutyl)cyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzaldehyde

HRID 290807Notes

Reaction equation

HRID 290807 reaction equation
[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[ClH:32].[Na+:34].[O:1]1[CH:2]([c:7]2[cH:8][c:9]([F:31])[c:10](-[c:13]3[s:14][c:15]4[n:16][c:17]([C:22]5([CH:25]6[CH2:26][C:27]([F:29])([F:30])[CH2:28]6)[CH2:23][CH2:24]5)[cH:18][cH:19][c:20]4[n:21]3)[cH:11][cH:12]2)[O:6][CH2:5][CH2:4][CH2:3]1.[OH-:33]>>[O:1]=[CH:2][c:7]1[cH:8][c:9]([F:31])[c:10](-[c:13]2[s:14][c:15]3[n:16][c:17]([C:22]4([CH:25]5[CH2:26][C:27]([F:29])([F:30])[CH2:28]5)[CH2:23][CH2:24]4)[cH:18][cH:19][c:20]3[n:21]2)[cH:11][cH:12]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 961HydroxideHCID 8028TetrahydrofuranHCID 671115762-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-5-(1-(3,3-difluoro-cyclobutyl)cyclopropyl)thiazolo[5,4-b]pyridine

Product 1

HCID 866387274-(5-(1-(3,3-Difluorocyclobutyl)cyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzaldehyde

Sources & evidence

ORD record
ord-10f5cfabb4b94d349f40cd7dc56d1fa9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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