Hydrochloric Acid → Tert-butyl 3-[[7-(2-morpholin-4-ylethoxy)naphthalen-2-yl]methoxy]-4-[4-(3-phenylmethoxypropoxy)phenyl]piperidine-1-carboxylate

HRID 291143Notes

Reaction equation

HRID 291143 reaction equation
[C:55](=[O:56])([O-:57])[O-:58].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[cH:14][cH:15][c:16]([CH:19]2[CH:20]([O:32][CH2:33][c:34]3[cH:35][c:36]4[cH:37][c:38]([OH:44])[cH:39][cH:40][c:41]4[cH:42][cH:43]3)[CH2:21][N:22]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:23][CH2:24]2)[cH:17][cH:18]1.[CH3:61][N:62]([CH3:63])[CH:64]=[O:65].[Cl:46][CH2:47][CH2:48][N:49]1[CH2:50][CH2:51][O:52][CH2:53][CH2:54]1.[ClH:45].[K+:59].[K+:60]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[cH:14][cH:15][c:16]([CH:19]2[CH:20]([O:32][CH2:33][c:34]3[cH:35][c:36]4[cH:37][c:38]([O:44][CH2:47][CH2:48][N:49]5[CH2:50][CH2:51][O:52][CH2:53][CH2:54]5)[cH:39][cH:40][c:41]4[cH:42][cH:43]3)[CH2:21][N:22]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:23][CH2:24]2)[cH:17][cH:18]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 767274-(2-Chloroethyl)morpholineHCID 57256197tert-butyl (3RS,4RS)-4-[4-(3-benzyloxy-propoxy)-phenyl]-3-(7-hydroxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

Product 1

HCID 54070201Tert-butyl 3-[[7-(2-morpholin-4-ylethoxy)naphthalen-2-yl]methoxy]-4-[4-(3-phenylmethoxypropoxy)phenyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-ae7d909caee1427bac55b54d7551b281
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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