Tetrahydrofuran → N-(4-chloro-3-(1-(3-(dimethylamino)propyl)-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide

HRID 291983Notes

Reaction equation

HRID 291983 reaction equation
[CH3:64][N:65]([CH2:66][CH2:67][CH2:68][OH:69])[CH3:70].[Cl:15][c:16]1[c:17](-[c:40]2[n:41][nH:42][cH:43][n:44]2)[c:18]([NH:21][C:22]([CH2:23][n:24]2[c:25](=[O:38])[cH:26][cH:27][c:28]3[cH:29][c:30]([C:34]([F:35])([F:36])[F:37])[cH:31][cH:32][c:33]23)=[O:39])[s:19][cH:20]1.[O:1]=[C:2]([O:3][CH:4]([CH3:5])[CH3:6])[N:7]=[N:8][C:9]([O:10][CH:11]([CH3:12])[CH3:13])=[O:14].[O:71]1[CH2:72][CH2:73][CH2:74][CH2:75]1.[c:45]1([P:46]([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[cH:59][cH:60][cH:61][cH:62][cH:63]1>>[Cl:15][c:16]1[c:17](-[c:40]2[n:41][n:42]([CH2:68][CH2:67][CH2:66][N:65]([CH3:64])[CH3:70])[cH:43][n:44]2)[c:18]([NH:21][C:22]([CH2:23][n:24]2[c:25](=[O:38])[cH:26][cH:27][c:28]3[cH:29][c:30]([C:34]([F:35])([F:36])[F:37])[cH:31][cH:32][c:33]23)=[O:39])[s:19][cH:20]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 766463-(Dimethylamino)-1-propanolHCID 178521249HCID 178521249, compound

Product 1

HCID 46869226N-(4-chloro-3-(1-(3-(dimethylamino)propyl)-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide

Sources & evidence

ORD record
ord-ba975acef0ac43fc964ce9bfdd90fcc6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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